What is Apoquel?
Apoquel is a pharmaceutical drug that is often prescribed to help combat inflammation and itching (in result of an allergy).
How does Apoquel Work?
Apoquel works as is part of the Janus kinase inhibitors. Janus kinase (JAK) is a family of intracellular, nonreceptor tyrosine kinases that transduce cytokine-mediated signals via the JAK-STAT pathway.
Cytokine signaling is an important part of the body regulation. Most cytokines are cell-secreted proteins from glial cells in the nervous system and are necessary for intracellular signaling. Macrophages and dendritic cells engulf foreign particles and send a cytokine signal to nearby dormant lymphocytes. (Regulates the immune system)
The immune system is the reason why a dog would experience “allergies” it’s the bodies way of recognising foreign bodies and expelling them by releasing antigens into the body which can often lead to the body excreting these “toxins” via the skin, which results in itching, dry skin, hot spots etc…
Now is there anything naturally that can do this job?
Well there are several food items that contain Ellagitannins, these are a superior JAK inhibitor! The best sources for your dogs would be Blackberries, Strawberries and Raspberries. Ellagitannins are a complex plant polyphenol, polyphenols are anti-inflammatory which is another intention of Apoquel. (not for a yeast dog)
Ellagitannins are a great way to support gut health and maintain healthy skin/fur. If your dog isn’t yeasty and you’ve removed the root cause and an allergy, then Ellagitannins could potentially help the body heal from within by Supporting the Microbiome.
Disclaimer: This isn’t meant to be used for medical accuracy, this is just an insight blog.